abstract：:Multifactorial metabolic diseases, such as non-alcoholic fatty liver disease, are a major burden to modern societies, and frequently present with no clearly defined molecular biomarkers. Herein we used system medicine approaches to decipher signatures of liver fibrosis in mouse models with malfunction in genes from un...

journal_title：International journal of molecular sciences

authors： Blagotinšek Cokan K,Urlep Ž,Moškon M,Mraz M,Kong XY,Eskild W,Rozman D,Juvan P,Režen T

更新日期：2021-01-15 00:00:00

abstract：:In the brewing process, the consumption of resources and the amount of waste generated are high and due to a lot of organic compounds in waste-water, the capacity of natural regeneration of the environment is exceeded. Residual yeast, the second by-product of brewing is considered to have an important chemical composi...

journal_title：International journal of molecular sciences

authors： Avramia I,Amariei S

更新日期：2021-01-15 00:00:00

abstract：:Chemotherapy is one of the most common strategies for tumor treatment but often associated with post-therapy tumor recurrence. While chemotherapeutic drugs are known to induce tumor cell senescence, the roles and mechanisms of senescence in tumor recurrence remain unclear. In this study, we used doxorubicin to induce ...

journal_title：International journal of molecular sciences

authors： Zhang N,Ji J,Zhou D,Liu X,Zhang X,Liu Y,Xiang W,Wang M,Zhang L,Wang G,Huang B,Lu J,Zhang Y

更新日期：2021-01-15 00:00:00

abstract：:Candida auris is a potential multidrug-resistant pathogen able to persist on indwelling devices as a biofilm, which serve as a source of catheter-associated infections. Neosartorya fischeri antifungal protein 2 (NFAP2) is a cysteine-rich, cationic protein with potent anti-Candida activity. We studied the in vitro acti...

journal_title：International journal of molecular sciences

authors： Kovács R,Nagy F,Tóth Z,Forgács L,Tóth L,Váradi G,Tóth GK,Vadászi K,Borman AM,Majoros L,Galgóczy L

更新日期：2021-01-14 00:00:00

abstract：:The use of animal models in fundamental or pre-clinical research remains an absolute requirement for understanding human pathologies and developing new drugs. In order to transpose these results into clinical practice, many parameters must be taken into account to limit bias. Attention has recently been focused on the...

journal_title：International journal of molecular sciences

authors： Dhot J,Prat V,Ferron M,Aillerie V,Erraud A,Rozec B,Waard M,Gauthier C,Lauzier B

更新日期：2021-01-14 00:00:00

abstract：:Inflammatory diseases are caused by excessive inflammation from pro-inflammatory mediators and cytokines produced by macrophages. The Nrf2 signaling pathway protects against inflammatory diseases by inhibiting excessive inflammation via the regulation of antioxidant enzymes, including HO-1 and NQO1. We investigated th...

journal_title：International journal of molecular sciences

authors： Lee GH,Kim JY,Jin SW,Pham TH,Park JS,Kim CY,Choi JH,Han EH,Kim YH,Jeong HG

更新日期：2021-01-14 00:00:00

abstract：:Synthetic organic dyes are widely used in various industrial sectors but are also among the most harmful water pollutants. In the last decade, significant efforts have been made to develop improved materials for the removal of dyes from water, in particular, on nanostructured adsorbent materials. Metal organic framewo...

journal_title：International journal of molecular sciences

authors： Delpiano GR,Tocco D,Medda L,Magner E,Salis A

更新日期：2021-01-14 00:00:00

abstract：:Tumor microenvironments are composed of a myriad of elements, both cellular (immune cells, cancer-associated fibroblasts, mesenchymal stem cells, etc.) and non-cellular (extracellular matrix, cytokines, growth factors, etc.), which collectively provide a permissive environment enabling tumor progression. In this revie...

journal_title：International journal of molecular sciences

authors： Liu Q,Aminu B,Roscow O,Zhang W

更新日期：2021-01-14 00:00:00

abstract：:The ocular surface has the challenging responsibility of maintaining a clear moist refractive surface while protecting the eye from exogenous pathogens and the environment. Homeostasis of the ocular surface, including its innate immune components, is altered in ocular surface disease states. In this review, we focus o...

journal_title：International journal of molecular sciences

authors： Eshac Y,Redfern RL,Aakalu VK

更新日期：2021-01-13 00:00:00

abstract：:Interleukin (IL)-4 and -13 are structurally and functionally related cytokines sharing common receptor subunits. They regulate immune responses and, moreover, are involved in the pathogenesis of a variety of human neoplasms. Three different receptors have been described for IL-4, but only IL-4 receptor type II (IL-4Rα...

journal_title：International journal of molecular sciences

authors： Song X,Traub B,Shi J,Kornmann M

更新日期：2021-01-13 00:00:00

abstract：:This work investigated in vitro aggregation and amyloid properties of skeletal myosin binding protein-C (sMyBP-C) interacting in vivo with proteins of thick and thin filaments in the sarcomeric A-disc. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) found a rapid (5-10 min) formation of large...

journal_title：International journal of molecular sciences

authors： Bobyleva LG,Shumeyko SA,Yakupova EI,Surin AK,Galzitskaya OV,Kihara H,Timchenko AA,Timchenko MA,Penkov NV,Nikulin AD,Suvorina MY,Molochkov NV,Lobanov MY,Fadeev RS,Vikhlyantsev IM,Bobylev AG

更新日期：2021-01-13 00:00:00

abstract：:The current emergence of multi-, extensively-, extremely-, and total-drug resistant strains of Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses the need to develop new therapeutic strategies. The notion of phage therapy against bacteria has been around for more than a century ...

journal_title：International journal of molecular sciences

authors： Allué-Guardia A,Saranathan R,Chan J,Torrelles JB

更新日期：2021-01-13 00:00:00

abstract：:Alzheimer's disease (AD), characterized by cognitive impairments, is considered to be one of the most widespread chronic neurodegenerative diseases worldwide. We recently introduced a novel therapeutic agent for AD treatment, the T-type calcium channel enhancer ethyl-8-methyl-2,4-dioxo-2-(piperidin-1-yl)-2H-spiro[cycl...

journal_title：International journal of molecular sciences

authors： Yuan D,Cheng A,Kawahata I,Izumi H,Xu J,Fukunaga K

更新日期：2021-01-13 00:00:00

abstract：:A novel quadruplex ligand based on 1,10-phenanthroline and incorporating two guanyl hydrazone functionalities, PhenQE8, is reported herein. Synthetic access was gained in a two-step procedure with an overall yield of 61%. X-ray diffraction studies revealed that PhenQE8 can adopt an extended conformation that may be op...

journal_title：International journal of molecular sciences

authors： Gratal PB,Quero JG,Pérez-Redondo A,Gándara Z,Gude L

更新日期：2021-01-13 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is the leading indication for heart transplantation. TTN gene truncating mutations account for about 25% of familial DCM cases and for 18% of sporadic DCM cases. The clinical relevance of specific variants in TTN has been difficult to determine because of the sheer size of the protein for ...

journal_title：International journal of molecular sciences

authors： Micaglio E,Monasky MM,Bernardini A,Mecarocci V,Borrelli V,Ciconte G,Locati ET,Piccoli M,Ghiroldi A,Anastasia L,Pappone C

更新日期：2021-01-12 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that have emerged as new potential epigenetic biomarkers. Here, we evaluate the efficacy of six circulating miRNA previously described in the literature as biomarkers for the diagnosis of temporal lobe epilepsy (TLE) and/or as predictive biomarkers to antiepileptic drug resp...

journal_title：International journal of molecular sciences

authors： De Benedittis S,Fortunato F,Cava C,Gallivanone F,Iaccino E,Caligiuri ME,Castiglioni I,Bertoli G,Manna I,Labate A,Gambardella A

更新日期：2021-01-12 00:00:00

abstract：:Since the European Union (EU) announced their animal testing ban in 2013, all animal experiments related to cosmetics have been prohibited, creating a demand for alternatives to animal experiments for skin studies. Here, we investigated whether an ex vivo live porcine skin model can be employed to study the safety and...

journal_title：International journal of molecular sciences

authors： Hwang JH,Jeong H,Lee N,Hur S,Lee N,Han JJ,Jang HW,Choi WK,Nam KT,Lim KM

更新日期：2021-01-11 00:00:00

abstract：:Neurodegenerative disorders can induce modifications of several proteins; one of which is ceruloplasmin (Cp), a ferroxidase enzyme found modified in the cerebrospinal fluid (CSF) of neurodegenerative diseases patients. Cp modifications are caused by the oxidation induced by the pathological environment and are usually...

journal_title：International journal of molecular sciences

authors： Zanardi A,Alessio M

更新日期：2021-01-11 00:00:00

abstract：:Osteoarthritis (OA) remains one of the common degenerative joint diseases and a major cause of pain and disability in older adult individuals. Oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) (such as diclofenac, DIC) or intra-articular injected gluco-corticosteroids (such as dexamethasone, DEX) w...

journal_title：International journal of molecular sciences

authors： Chang MC,Chiang PF,Kuo YJ,Peng CL,Chen KY,Chiang YC

更新日期：2021-01-11 00:00:00

abstract：:Endothelial cells and astrocytes preferentially express metabotropic P2Y nucleotide receptors, which are involved in the maintenance of vascular and neural function. Among these, P2Y1 and P2Y2 receptors appear as main actors, since their stimulation induces intracellular calcium mobilization and activates signaling ca...

journal_title：International journal of molecular sciences

authors： Gil-Redondo JC,Iturri J,Ortega F,Pérez-Sen R,Weber A,Miras-Portugal MT,Toca-Herrera JL,Delicado EG

更新日期：2021-01-10 00:00:00

abstract：:Dietary salt uptake and inflammation promote sodium accumulation in tissues, thereby modulating cells like macrophages and fibroblasts. Previous studies showed salt effects on periodontal ligament fibroblasts and on bone metabolism by expression of nuclear factor of activated T-cells-5 (NFAT-5). Here, we investigated ...

journal_title：International journal of molecular sciences

authors： Schröder A,Gubernator J,Leikam A,Nazet U,Cieplik F,Jantsch J,Neubert P,Titze J,Proff P,Kirschneck C

更新日期：2021-01-09 00:00:00

abstract：:Nicotine addiction is a severe public health problem. The aim of this study was to investigate the alterations in key neurotransmissions after 60 days of withdrawal from seven weeks of intermittent cigarette smoke, e-cigarette vapours, or an e-cigarette vehicle. In the nicotine withdrawal groups, increased depressive ...

journal_title：International journal of molecular sciences

authors： Carboni L,Ponzoni L,Braida D,Sala M,Gotti C,Zoli M

更新日期：2021-01-09 00:00:00

abstract：:In 1937, Sir H. A Krebs first published the Citric Acid Cycle, a unidirectional cycle with carboxylic acids. The original concept of the Citric Acid Cycle from Krebs' 1953 Nobel Prize lecture illustrates the unidirectional degradation of lactic acid to water, carbon dioxide and hydrogen. Here, we add the heart lactate...

journal_title：International journal of molecular sciences

authors： Roosterman D,Cottrell GS

更新日期：2021-01-09 00:00:00

abstract：:Ankyrin repeat (AR) domains are considered the most abundant repeat motif found in eukaryotic proteins. AR domains are predominantly known to mediate specific protein-protein interactions (PPIs) without necessarily recognizing specific primary sequences, nor requiring strict conformity within its own primary sequence....

journal_title：International journal of molecular sciences

authors： Kane EI,Spratt DE

更新日期：2021-01-09 00:00:00

abstract：:The evaluation of antioxidant compounds that counteract the mutagenic effects caused by the direct action of reactive oxygen species on DNA molecule is of considerable interest. Therefore, a series of 2,3-substituted quinazolinone derivatives (Q1-Q8) were investigated by different assays, and the relationship between ...

journal_title：International journal of molecular sciences

authors： Hricovíniová J,Hricovíniová Z,Kozics K

更新日期：2021-01-09 00:00:00

abstract：:Lung cancer is the leading cause of death for malignancy worldwide. Its molecular profiling has enriched our understanding of cancer initiation and progression and has become fundamental to provide guidance on treatment with targeted therapies. Testing the presence of driver mutations in specific genes in lung tumors ...

journal_title：International journal of molecular sciences

authors： Fois SS,Paliogiannis P,Zinellu A,Fois AG,Cossu A,Palmieri G

更新日期：2021-01-09 00:00:00

abstract：:β-lactam antibiotics are among the most important and widely used antimicrobials worldwide and are comprised of a large family of compounds, obtained by chemical modifications of the common scaffolds. Usually these modifications include the addition of active groups, but less frequently, molecules were synthesized in ...

journal_title：International journal of molecular sciences

authors： De Rosa M,Verdino A,Soriente A,Marabotti A

更新日期：2021-01-09 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a human pathogenic herpesvirus associated with a variety of clinical symptoms. Current antiviral therapy is not always effective, so that improved drug classes and drug-targeting strategies are needed. Particularly host-directed antivirals, including pharmaceutical kinase inhibitors (PK...

journal_title：International journal of molecular sciences

authors： Wild M,Kicuntod J,Seyler L,Wangen C,Bertzbach LD,Conradie AM,Kaufer BB,Wagner S,Michel D,Eickhoff J,Tsogoeva SB,Bäuerle T,Hahn F,Marschall M

更新日期：2021-01-08 00:00:00

abstract：:The nosocomial opportunistic Gram-negative bacterial pathogen Acinetobacter baumannii is resistant to multiple antimicrobial agents and an emerging global health problem. The polymyxin antibiotic colistin, targeting the negatively charged lipid A component of the lipopolysaccharide on the bacterial cell surface, is of...

journal_title：International journal of molecular sciences

authors： Chamoun S,Welander J,Martis-Thiele MM,Ntzouni M,Claesson C,Vikström E,Turkina MV

更新日期：2021-01-08 00:00:00

abstract：:Neurodegenerative diseases are characterized by adverse cellular environments and pathological alterations causing neurodegeneration in distinct brain regions. This development is triggered or facilitated by conditions such as hypoxia, ischemia or inflammation and is associated with disruptions of fundamental cellular...

journal_title：International journal of molecular sciences

authors： Burtscher J,Maglione V,Di Pardo A,Millet GP,Schwarzer C,Zangrandi L

更新日期：2021-01-08 00:00:00

abstract：:The aim of this study was to develop and evaluate matrix assisted LASER desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry imaging (MSI) of blood smear. Integrated light microscope and MALDI IT-TOF mass spectrometer, together with a matrix sublimation device, were used for analysis of blood smears co...

journal_title：International journal of molecular sciences

authors： Debeljak Ž,Niehoff AC,Bandjak A,Mandić D,Bošnjak B,Heffer M,Mrđenović S,Marković I,Zjalić M,Šerić V

更新日期：2021-01-08 00:00:00

abstract：:Cell competition (CC) is a feature that allows tumor cells to outcompete and eliminate adjacent cells that are deemed less fit. Studies of CC, first described in Drosophila melanogaster, reveal a diversity of underlying mechanisms. In this review, we will discuss three recent studies that expand our understanding of t...

journal_title：International journal of molecular sciences

authors： Ferrari AJ,Drapkin R,Gogna R

更新日期：2021-01-07 00:00:00

abstract：:Neurons are structurally unique and have dendrites and axons that are vulnerable to injury. Some neurons in the peripheral nervous system (PNS) can regenerate their axons after injuries. However, most neurons in the central nervous system (CNS) fail to do so, resulting in irreversible neurological disorders. To unders...

journal_title：International journal of molecular sciences

authors： Lee B,Cho Y

更新日期：2021-01-06 00:00:00

abstract：:Transforming growth factor β (TGFβ) is a secreted growth and differentiation factor that influences vital cellular processes like proliferation, adhesion, motility, and apoptosis. Regulation of the TGFβ signaling pathway is of key importance to maintain tissue homeostasis. Perturbation of this signaling pathway has be...

journal_title：International journal of molecular sciences

authors： Sinha A,Iyengar PV,Ten Dijke P

更新日期：2021-01-06 00:00:00

abstract：:It is widely recognized that many chronic infections of the human body have a polymicrobial etiology. These include diabetic foot ulcer infections, lung infections in cystic fibrosis patients, periodontitis, otitis, urinary tract infections and even a proportion of systemic infections. The treatment of mixed infection...

journal_title：International journal of molecular sciences

authors： Batoni G,Maisetta G,Esin S

更新日期：2021-01-06 00:00:00

abstract：:The anti-stress potential of dietary L-arginine (Arg) was assessed in psychosocially stress-loaded senescence-accelerated (SAMP10) mice. Although this strain of mouse is sensitive to stress, daily administration of Arg at 3 mg/kg significantly suppressed aging-related cognitive decline and behavioral depression at nin...

journal_title：International journal of molecular sciences

authors： Pervin M,Unno K,Konishi T,Nakamura Y

更新日期：2021-01-06 00:00:00

abstract：:An ongoing challenge in functional epigenomics is to develop tools for precise manipulation of epigenetic marks. These tools would allow moving from correlation-based to causal-based findings, a necessary step to reach conclusions on mechanistic principles. In this review, we describe and discuss the advantages and li...

journal_title：International journal of molecular sciences

authors： Fal K,Tomkova D,Vachon G,Chabouté ME,Berr A,Carles CC

更新日期：2021-01-06 00:00:00

abstract：:Glioblastoma (GBM) is the most common malignant brain tumor and its malignant phenotypic characteristics are classified as grade IV tumors. Molecular interactions, such as protein-protein, protein-ncRNA, and protein-peptide interactions are crucial to transfer the signaling communications in cellular signaling pathway...

journal_title：International journal of molecular sciences

authors： Gnanavel M,Murugesan A,Konda Mani S,Yli-Harja O,Kandhavelu M

更新日期：2021-01-06 00:00:00

abstract：:DNA G-quadruplexes (G4s) form in relevant genomic regions and intervene in several biological processes, including the modulation of oncogenes expression, and are potential anticancer drug targets. The human KRAS proto-oncogene promoter region contains guanine-rich sequences able to fold into G4 structures. Here, by u...

journal_title：International journal of molecular sciences

authors： D'Aria F,Pagano B,Petraccone L,Giancola C

更新日期：2021-01-05 00:00:00

abstract：:Niemann-Pick disease type C (NPC) is a recessive hereditary disease caused by mutation of the NPC1 or NPC2 gene. It is characterized by abnormality of cellular cholesterol trafficking with severe neuronal and hepatic injury. In this study, we investigated the potential of glycoprotein nonmetastatic melanoma protein B ...

journal_title：International journal of molecular sciences

authors： Fukaura M,Ishitsuka Y,Shirakawa S,Ushihama N,Yamada Y,Kondo Y,Takeo T,Nakagata N,Motoyama K,Higashi T,Arima H,Kurauchi Y,Seki T,Katsuki H,Higaki K,Matsuo M,Irie T

更新日期：2021-01-05 00:00:00